authentic standards for metabolites Search Results


authentic metabolite standards  (Onyx Pharmaceuticals)
90
Onyx Pharmaceuticals authentic metabolite standards
In vitro metabolism of oprozomib in human hepatocytes. (A) Representative ion chromatograms of oprozomib metabolites formed in human hepatocytes. Dash line: control sample, cell suspensions spiked with oprozomib; solid line: cell suspensions after 1-hour incubation with oprozomib. (B) Quantitative oprozomib (OPZ) disappearance and <t>metabolite</t> formation in human hepatocytes. At each time point, the levels of oprozomib, PR-176, and PR-025 diol in cell suspensions were quantified and then normalized as the percentage of initial oprozomib concentration at zero minutes. Data represent mean ± S.D. from three replicate incubations. PR-176 was the predominant metabolite formed via epoxide hydrolysis within 1-hour incubation.
Authentic Metabolite Standards, supplied by Onyx Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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authentic standards of sesamin metabolites sc-1 and sc-2  (Nemoto Science Co Ltd)
90
Nemoto Science Co Ltd authentic standards of sesamin metabolites sc-1 and sc-2
In vitro metabolism of oprozomib in human hepatocytes. (A) Representative ion chromatograms of oprozomib metabolites formed in human hepatocytes. Dash line: control sample, cell suspensions spiked with oprozomib; solid line: cell suspensions after 1-hour incubation with oprozomib. (B) Quantitative oprozomib (OPZ) disappearance and <t>metabolite</t> formation in human hepatocytes. At each time point, the levels of oprozomib, PR-176, and PR-025 diol in cell suspensions were quantified and then normalized as the percentage of initial oprozomib concentration at zero minutes. Data represent mean ± S.D. from three replicate incubations. PR-176 was the predominant metabolite formed via epoxide hydrolysis within 1-hour incubation.
Authentic Standards Of Sesamin Metabolites Sc 1 And Sc 2, supplied by Nemoto Science Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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authentic standards for metabolites  (Celgene)
90
Celgene authentic standards for metabolites
In vitro metabolism of oprozomib in human hepatocytes. (A) Representative ion chromatograms of oprozomib metabolites formed in human hepatocytes. Dash line: control sample, cell suspensions spiked with oprozomib; solid line: cell suspensions after 1-hour incubation with oprozomib. (B) Quantitative oprozomib (OPZ) disappearance and <t>metabolite</t> formation in human hepatocytes. At each time point, the levels of oprozomib, PR-176, and PR-025 diol in cell suspensions were quantified and then normalized as the percentage of initial oprozomib concentration at zero minutes. Data represent mean ± S.D. from three replicate incubations. PR-176 was the predominant metabolite formed via epoxide hydrolysis within 1-hour incubation.
Authentic Standards For Metabolites, supplied by Celgene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ilg metabolites butein and sulfarein  (INDOFINE Inc)
90
INDOFINE Inc ilg metabolites butein and sulfarein
In vitro metabolism of oprozomib in human hepatocytes. (A) Representative ion chromatograms of oprozomib metabolites formed in human hepatocytes. Dash line: control sample, cell suspensions spiked with oprozomib; solid line: cell suspensions after 1-hour incubation with oprozomib. (B) Quantitative oprozomib (OPZ) disappearance and <t>metabolite</t> formation in human hepatocytes. At each time point, the levels of oprozomib, PR-176, and PR-025 diol in cell suspensions were quantified and then normalized as the percentage of initial oprozomib concentration at zero minutes. Data represent mean ± S.D. from three replicate incubations. PR-176 was the predominant metabolite formed via epoxide hydrolysis within 1-hour incubation.
Ilg Metabolites Butein And Sulfarein, supplied by INDOFINE Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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authentic standard of the metabolites  (Daiichi Sankyo)
90
Daiichi Sankyo authentic standard of the metabolites
In vitro metabolism of oprozomib in human hepatocytes. (A) Representative ion chromatograms of oprozomib metabolites formed in human hepatocytes. Dash line: control sample, cell suspensions spiked with oprozomib; solid line: cell suspensions after 1-hour incubation with oprozomib. (B) Quantitative oprozomib (OPZ) disappearance and <t>metabolite</t> formation in human hepatocytes. At each time point, the levels of oprozomib, PR-176, and PR-025 diol in cell suspensions were quantified and then normalized as the percentage of initial oprozomib concentration at zero minutes. Data represent mean ± S.D. from three replicate incubations. PR-176 was the predominant metabolite formed via epoxide hydrolysis within 1-hour incubation.
Authentic Standard Of The Metabolites, supplied by Daiichi Sankyo, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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authentic metabolite standards  (Taisho Pharmaceutical Co Ltd)
90
Taisho Pharmaceutical Co Ltd authentic metabolite standards
Composition of the metabolites of the drug in the urine and feces of rats and dogs after a single oral administration of [ 14 C]vornorexant (3 mg/kg).
Authentic Metabolite Standards, supplied by Taisho Pharmaceutical Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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authentic metabolite standards  (Eisai Inc)
90
Eisai Inc authentic metabolite standards
Composition of the metabolites of the drug in the urine and feces of rats and dogs after a single oral administration of [ 14 C]vornorexant (3 mg/kg).
Authentic Metabolite Standards, supplied by Eisai Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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authentic standards of the metabolites m1 to m4  (Yoshitomi Pharmaceutical Industries)
90
Yoshitomi Pharmaceutical Industries authentic standards of the metabolites m1 to m4
Composition of the metabolites of the drug in the urine and feces of rats and dogs after a single oral administration of [ 14 C]vornorexant (3 mg/kg).
Authentic Standards Of The Metabolites M1 To M4, supplied by Yoshitomi Pharmaceutical Industries, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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authentic metabolite standards for m1, m2, m3 and m17  (Taisho Pharmaceutical Co Ltd)
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Taisho Pharmaceutical Co Ltd authentic metabolite standards for m1, m2, m3 and m17
Composition of the metabolites of the drug in the urine and feces of rats and dogs after a single oral administration of [ 14 C]vornorexant (3 mg/kg).
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authentic standard metabolites m5, m7, m8, m11, m17, and m18  (Eli Lilly)
90
Eli Lilly authentic standard metabolites m5, m7, m8, m11, m17, and m18
Composition of the metabolites of the drug in the urine and feces of rats and dogs after a single oral administration of [ 14 C]vornorexant (3 mg/kg).
Authentic Standard Metabolites M5, M7, M8, M11, M17, And M18, supplied by Eli Lilly, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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authentic metabolite standard database  (Human Metabolome Technologies America)
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Human Metabolome Technologies America authentic metabolite standard database
Composition of the metabolites of the drug in the urine and feces of rats and dogs after a single oral administration of [ 14 C]vornorexant (3 mg/kg).
Authentic Metabolite Standard Database, supplied by Human Metabolome Technologies America, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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authentic standards of methylone metabolites  (Shima Laboratories)
90
Shima Laboratories authentic standards of methylone metabolites
Composition of the metabolites of the drug in the urine and feces of rats and dogs after a single oral administration of [ 14 C]vornorexant (3 mg/kg).
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Image Search Results


In vitro metabolism of oprozomib in human hepatocytes. (A) Representative ion chromatograms of oprozomib metabolites formed in human hepatocytes. Dash line: control sample, cell suspensions spiked with oprozomib; solid line: cell suspensions after 1-hour incubation with oprozomib. (B) Quantitative oprozomib (OPZ) disappearance and metabolite formation in human hepatocytes. At each time point, the levels of oprozomib, PR-176, and PR-025 diol in cell suspensions were quantified and then normalized as the percentage of initial oprozomib concentration at zero minutes. Data represent mean ± S.D. from three replicate incubations. PR-176 was the predominant metabolite formed via epoxide hydrolysis within 1-hour incubation.

Journal: Drug Metabolism and Disposition

Article Title: In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s

doi: 10.1124/dmd.117.075226

Figure Lengend Snippet: In vitro metabolism of oprozomib in human hepatocytes. (A) Representative ion chromatograms of oprozomib metabolites formed in human hepatocytes. Dash line: control sample, cell suspensions spiked with oprozomib; solid line: cell suspensions after 1-hour incubation with oprozomib. (B) Quantitative oprozomib (OPZ) disappearance and metabolite formation in human hepatocytes. At each time point, the levels of oprozomib, PR-176, and PR-025 diol in cell suspensions were quantified and then normalized as the percentage of initial oprozomib concentration at zero minutes. Data represent mean ± S.D. from three replicate incubations. PR-176 was the predominant metabolite formed via epoxide hydrolysis within 1-hour incubation.

Article Snippet: Oprozomib and authentic metabolite standards were synthesized and characterized at Onyx Pharmaceuticals, an Amgen subsidiary (South San Francisco, CA).

Techniques: In Vitro, Control, Incubation, Concentration Assay

Composition of the metabolites of the drug in the urine and feces of rats and dogs after a single oral administration of [ 14 C]vornorexant (3 mg/kg).

Journal: Pharmacology Research & Perspectives

Article Title: Preclinical metabolism and the disposition of vornorexant/TS‐142, a novel dual orexin 1/2 receptor antagonist for the treatment of insomnia

doi: 10.1002/prp2.1183

Figure Lengend Snippet: Composition of the metabolites of the drug in the urine and feces of rats and dogs after a single oral administration of [ 14 C]vornorexant (3 mg/kg).

Article Snippet: Vornorexant and authentic metabolite standards were synthesized at Taisho Pharmaceutical (Saitama, Japan).

Techniques: